Determination of Moxonidine and Its Impurities by Thin-Layer Chromatography

A thin-layer chromatographic method for simultaneous determination of moxonidine and its four impurities was developed and validated. Separation of the examined compounds was performed on chromatographic plates precoated with silica gel 60F(254) and using methanol-toluene-dichloroethane-ammonia 2:3:3:0.1 (v/v/v/v) as mobile phase. Ascending development mode was performed in the twin-trough chromatographic chamber, which was presaturated with mobile phase vapors for 15min. The developed chromatographic plates were dried in air and densitometrically scanned at the wavelengths of 260 and 280nm. Regression coefficients (r >= 0.998), recovery (90.10-107.63%), limit of quantification of impurities (20ng band(-1) equivalent to the 0.12% impurity level), and robustness were validated and found satisfactory. The developed method is well suited for quantitative analysis and purity control of moxonidine in its dosage forms.This is peer-reviewed version of the following article: Filipic, S.; Shenger, M. S. M.; Nikolic, K.; Agbaba, D. Determination of Moxonidine and Its Impurities by Thin-Layer Chromatography. J. Liq. Chromatogr. Relat. Technol. 2015, 38 (11), 1121–1125. [https://doi.org/10.1080/10826076.2015.1028291

Machine learning for single-user ultra wideband wireless communication systems

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Estimation of lipophilicity and retention behavior of some alpha adrenergic and imidazoline receptor ligands using rp-tlc

The chromatographic behavior of 16 alpha adrenergic and imidazoline receptor ligands has been studied by reversed-phase thin-layer chromatography (RP-TLC) on RP-18 and CN stationary phases. Retention constant R-M(0) was determined for all tested compounds in three different chromatographic systems: methanol-water/RP-18, tetrahydrofuran-ammonia-water/RP-18, and tetrahydrofuran-ammonia-water/CN. Good correlations between determined hydrophobic parameters R-M(0) and calculated log P values were obtained for the system tetrahydrofuran-ammonia-water on both RP-18 and CN stationary phases. Experimentally obtained R-M(0) values and computed molecular parameters of the examined compounds were further used for the quantitative structure-retention relationship (QSRR) study, in order to determine the most important properties governing retention. The QSRR modeling was performed with use of the partial least squares regression, and predictive performances of the developed QSRR models were tested by use of the cross-validation and external test set prediction. The created models revealed that apart from lipophilicity, constitutional descriptors, the amount of van der Waals surface area having a property P (P_VSA-like descriptors), and hydrogen bonding properties of the tested compounds were important for the retention behavior in the RP-TLC systems

Proceedings of First Conference for Engineering Sciences and Technology: Vol. 2

This volume contains contributed articles of Track 4, Track 5 & Track 6, presented in the conference CEST-2018, organized by Faculty of Engineering Garaboulli, and Faculty of Engineering, Al-khoms, Elmergib University (Libya) on 25-27 September 2018. Track 4: Industrial, Structural Technologies and Science Material Track 5: Engineering Systems and Sustainable Development Track 6: Engineering Management Other articles of Track 1, 2 & 3 have been published in volume 1 of the proceedings at this lin

Proceedings of First Conference for Engineering Sciences and Technology: Vol. 1

This volume contains contributed articles of Track 1, Track 2 & Track 3, presented in the conference CEST-2018, organized by Faculty of Engineering Garaboulli, and Faculty of Engineering, Al-khoms, Elmergib University (Libya) on 25-27 September 2018. Track 1: Communication and Information Technology Track 2: Electrical and Electronics Engineering Track 3: Oil and Chemical Engineering Other articles of Track 4, 5 & 6 have been published in volume 2 of the proceedings at this lin